ABSTRACT
Adequate preventive specific and unspecific and therapeutic procedures are urgently required for the new incoming generation of viruses;some strategies approached the infections with chemotherapies adopted from previous antiviral programs or with off label drugs. The optimal goal would be to practice a widespread treatment safe, effective, sustainable, cheap as much as possible. The enhancement of innate immunity defenses and the support of the trained immunity are very helpful aside of the incoming vaccines. Innate immunity is the most ancient ready and quick defense against pathogens of al the living species: it commits phagocytic cells to directly get rid of the infectious agents, while the trained immunity is expressed by the adaptive immunity a late evolutionary phase (2 million years after the innate one): the antibodies producing immunological memory is usually tailored against specific antigens but can be expanded eliciting an immune response against other infecting noxa. This paper deals with the clinical history and revival of C. parvum, a killed commensal bacterium located in the sebaceous glands with strong unspecific antitumoral and antiviral innate immunity enhancing properties that can profitably be updated in hazardous infectious emergencies.